Optic Nerve Sheath Diameter in Retrobulbar Ultrasound as a Surrogate Measure for Intracranial Pressure Before and After Non-invasive Strategies

Hospital Dr. Miguel Pérez Carreño90 enrolled

Overview

Measurement of the diameter of the sheath of the optic nerve in patients hospitalized in intensive care, with increased intracranial pressure (\> 20mmHg) as a substitute measure for diagnosis and follow-up before and after different non-invasive strategies. Three groups were created in which, through strategies already proven and non-invasive (mannitol, hypertonic solution 7.5% NaCl, reverse trendelenburg) to decrease the intracranial pressure, the optic nerve diameter measurement was performed and simultaneously the investigators monitored intracranial pressure through an intraventricular catheter continuously to determine if both correspond

Study Type

OBSERVATIONAL

Enrollment

Conditions

Intracranial Hypertension Optic Nerve Sheath Diameter

Interventions

optical nerve sheet diameterDIAGNOSTIC_TEST

The ONSD in each eye was measured vertically and horizontally 3 mm behind the optic disc, with the two values averaged. No pressure was applied to the orbit. At each time point, measurements were taken within 5 min. The measurements were made before (T1) and after some of the strategies according to group 30 min (T2), 60 min (T3), and 90 min (T4).

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patients (≥ 18 years old) with traumatic or non-traumatic elevated ICP (defined as greater than 20 mm Hg for at least 10min) * Hospitalized in ICU * Patients with ICP continuous measurement through an intraventricular catheter * Respiratory rate maintained at 10-18 breaths/min to maintain the end tidal carbon dioxide partial pressure between 35 and 40 mmHg * Peak airway pressure \<35 cmH2O * Positive end-expiratory pressure \<5 cmH2O Exclusion Criteria: * Patients who had undergone cranial decompression surgery * Patients with ocular pathology * Patients who had previously undergone eye surgery

Outcomes

Primary Outcomes

Optic nerve sheet diameter

The optic nerve sheet diameter in each eye was measured vertically and horizontally 3 mm behind the optic disc, with the two values averaged

Time frame: immediately before administering the treatment according to the group and every 30 minutes after administering the treatment until 90 min.