The PK/PD Study of A Single Subcutaneous Injection of SHR-1209 in Healthy Subjects

Inclusion Criteria: 1. Age ≥18 and ≤45 years old; 2. The body mass index (BMI) should be 19 or greater and \< 28kg/m2, the male weigh ≥50.0kg and \<90.0kg, and the female weigh ≥45.0kg and \<90.0kg; 3. Serum LDL-C concentration≥2.0mmol/L and \< 4.1mmol/L; 4. Fasting triglycerides \< 2.3 mmol/L; 5. The comprehensive physical examination is eligible or slightly abnormal but the researchers determine no clinical implication. 6. Signed informed consent. Exclusion Criteria: 1. Subjects determined by the researchers have diseases that affect drug absorption, distribution, metabolism and excretion or low compliance; 2. A clinical history of drug allergy or a history of atopic allergic diseases (asthma, urticaria, eczema dermatitis) or a known allergy to experimental or similar experimental drugs; 3. Serum creatinine exceeded the upper limit of normal value (ULN) during screening; 4. Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) or gamma pancreatic acyl transferase (GGT), more than 2 x ULN, or total bilirubin more than 1.5 x ULN during screening; 5. Human immunodeficiency virus antibody (HIV-ab), syphilis serological examination, hepatitis b virus surface antigen (HBsAg), hepatitis c virus antibody (HCV-ab) were positive; 6. Subjects with previous malignant tumor diseases; 7. 3 months prior to screening involved in any drug or medical device clinical subjects, or within 5 half-life of drugs (test drug half-life more than 3 months) before screening. etc