Effect of N_Acetylcysteine on Liver Functions in Donors in Living Liver Transplantation

Ain Shams University50 enrolled

Overview

our practice for the past 10 years we have noticed a transitional impairment of liver function (elevated liver enzymes, total and direct bilirubin, and elevated serum lactate levels) following donors' liver resection. Several drugs have been investigation on liver regeneration , proven benefit of N-Acetylcysteine (NAC) on rats with steatohpatitis

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Liver Transplant; Complications

Interventions

N-AcetylecysteineDRUG

N-Acetylecysteine 150 mg/kg diluted in 100 ml glucose 5 % over 40 minutes followed by NAC 12.5 mg/kg in 500 ml glucose 5% over 4 hours, followed by NAC 6.25 mg/kg for 2 postoperative days

PlaceboDRUG

Ringer acetate continuous infusion at the same rate for 2 days.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ASA I or II donors * healthy adult Exclusion Criteria: * kidney, liver disease * any contraindications for organ donation

Locations (1)

Faculty of medicine

Cairo, Egypt

Outcomes

Primary Outcomes

Serum lactate

Time frame: 24 hours postoperative

Data from ClinicalTrials.gov

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