The purpose of this study is to evaluate the effects of the experimental medication BMS-986256 in healthy participants.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
118
Specified dose on specified days
Specified dose on specified days
Anaheim Clinical Trials
Anaheim, California, United States
PRA Health Science KK
Lenexa, Kansas, United States
Number of Serious Adverse Events (SAE)
Time frame: Up to 46 days
Number of deaths
Time frame: Up to 46 days
Number of clinically significant changes in ECG, vital signs, physical examination findings, or clinical laboratory assessments
Time frame: Up to 44 days
Number of Adverse Events (AEs) leading to early discontinuation
Time frame: Up to 44 days
Maximum concentration (Cmax)
Time frame: Up to 44 days
Time of maximum concentration (Tmax)
Time frame: Up to 44 days
Area under the plasma concentration-time curve from time 0 to the last quantifiable concentration [AUC(0-T)]
Time frame: Up to 44 days
Area under the plasma concentration-time curve extrapolated to infinity [AUC(INF)]
Time frame: Up to 44 days
Terminal elimination rate constant (kel)
Time frame: Up to 44 days
Terminal elimination half-life (T-half)
Time frame: Up to 44 days
Apparent oral clearance (CL/F)
Time frame: Up to 44 days
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Metabolite ratio for AUC(INF) [MR(AUC[INF])]
Time frame: Up to 44 days
Metabolite ratio of Cmax [MR(Cmax)]
Time frame: Up to 44 days
Apparent volume of distribution at terminal phase (Vz/F)
Time frame: Up to 44 days
Plasma concentration immediately prior to dosing (Ctrough)
Time frame: Up to 44 days
Area under the plasma concentration-time curve over the dosing interval [AUC(TAU)]
Time frame: Up to 44 days
Accumulation ratio of Ctrough [AR(Ctrough)]
Time frame: Up to 44 days
Accumulation ratio of AUC(TAU) [AR(AUC[TAU])]
Time frame: Up to 44 days
Accumulation ratio of Cmax [AR(Cmax)]
Time frame: Up to 44 days
Metabolite ratio for AUC(TAU) [MR(AUC[TAU])]
Time frame: Up to 44 days