Automated Screen for Fetal Aneuploidy

Inclusion Criteria: 1. Subject is at least 18 years old and can provide informed consent; 2. Subject has a viable singleton or twin pregnancy; 3. Subject is confirmed to be at least 10 weeks, 0 days gestation at the time of the study blood draw; 4. Subject is planning to undergo chorionic villus sampling and/or amniocentesis for the purpose of genetic analysis of the fetus because of a suspected fetal chromosomal anomaly based on cell-free DNA test results, standard serum screening result, or fetal ultrasound abnormality. 5. OR the subject has already undergone chorionic villus sampling and/or amniocentesis and is known to have a fetus with a chromosomal abnormality confirmed by genetic analysis. Exclusion Criteria: 1. Subject (the mother) has known aneuploidy; 2. Subject is pregnant with more than two fetuses or has had sonographic evidence of three or more gestational sacs at any time during pregnancy; 3. Subject has a fetal demise (including natural or elective reduction) identified prior to consent; 4. Subject has history of malignancy treated with chemotherapy and/or major surgery, or bone marrow transplant.