The Impact of Artificial Sunlight on Human Sleep and Circadian Rhythms

VA Palo Alto Health Care System10 enrolled

Overview

The purpose of this study is to examine, in healthy controls, whether LED lighting that has a color spectrum similar to that of sunlight is able to differentially impact mood, circadian rhythms, sleep, and behavior, as compared to standard fluorescent lighting.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Sleep Circadian Dysregulation Mood

Interventions

LightDEVICE

15 hours of light exposure

Eligibility

Sex: ALLMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Good self-reported health * Normal color vision Exclusion Criteria: * No sleep disorders * No extreme chronotype * Regular smoker * Significant hearing loss * Depression * Alcohol use disorder * Use of illegal drugs * Pregnant

Locations (1)

VA Palo Alto Health Care System

Palo Alto, California, United States

Outcomes

Primary Outcomes

Alertness

Change in median reaction time score on the auditory psychomotor vigilance test

Time frame: 15 hours

Melatonin suppression

Amount of reduction in the concentration of salivary melatonin concentrations during an experimental light stimulus

Time frame: 3 hours

Secondary Outcomes

Mood

Change in total positive and negative affect scores on the Positive and Negative Affect Schedule (PANAS)

Time frame: 15 hours

Data from ClinicalTrials.gov

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