Randomized crossover Trial in patients with Pulmonary Hypertension (PAH, CTEPH) to assess the acute response to High Altitude (2500m above sea level) in constant loaded exercise capacity.
Low altitude baseline measurements will be performed in Zurich (460m asl) including Echocardiography, Right heart catheterization, 6MWT, pulmonary function test, clinical assessment and blood gas Analysis. Randomly assigned to the order of testing, the participants will be tested in Low Altitude (Zurich, 470m) and at High Altitude (2500m). Towards the end of the exposure after approximately 4 hours, the participants will perform a constant loaded exercise test on an Ergometer with a calculated resistance of their 60% max Workload. The patients will be encouraged to perform these tests up to their physical exhaustion.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
28
Assessment at Low Altitude (in Zurich; 470m above sea level) in order to compare this data with High altitude exposure
Exposure to High Altitude (Säntis; 2500m above sea level) for approximately 5 hours
Respiratory Clinic, University Hospital of Zurich
Zurich, Switzerland
endurance time at High Altitude
The time of a constant loaded exercise test by an ergometer in sitting position at High Altitude will be compared with the same test at low altitude (370m above sea level)
Time frame: 1 day at altitude
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