Baby Albert: Electronic Cigarette Pharmacokinetics (PK) and Abuse Liability

Inclusion Criteria: * be at least 18 years old * live within 30 miles of the research site * interested in/willing to use an e-cigarette during study visits * be willing and able to complete study procedures including specimen collection, survey completion, and remaining nicotine abstinent for 12 hours prior to each study visit * speak and understand English * willing to provide informed consent * bring usual brand cigarettes to screener study visit * should have healthy veins Additional Inclusion criteria for smokers: * smoke at least 10 cigarettes per day for the past three months * exhaled more than equal to 6 ppm carbon monoxide at the screener visit Additional Inclusion criteria for dual users: * smoke more than equal to 5 tobacco cigarettes per day for the last 3 months * use e-cigarettes at least 15 days per month for the last 3 months, and * bring e-cigarette device to screener study visit Exclusion Criteria: * currently suffering from lung disease including asthma, cystic fibrosis (CF), or chronic obstructive pulmonary disease (COPD), unless it is well-controlled * currently pregnant or breast-feeding or have plans to become pregnant or begin breast-feeding at any point during the study * intoxicated at study visits (breath alcohol testing and clean urine drug screen) * any known allergies or sensitivity to the known major constituents contained in the aerosol of the study e-cigarette devices (e.g., flavorants, vegetable glycerin, propylene glycol) * User of zero-nicotine e-cigarettes * history of cardiac event or distress within the past 3 months * currently suffering from any blood disorder that includes von willebrand, hemophilia, anemia, sickle cell, leukopenia, thrombocytopenia * currently taking an anticoagulant or blood thinning medications * have stent, graph, mastectomy or artificial hardware placed in arms or hands (bilaterally) Additional Exclusion criteria for smokers: * have previously used any e-cigarette device (cig-a-like, pen style, mod, APV) for longer than 30 days * use of an e-cigarette device over the past 14 days.