Cell-free Fetal DNA Concentration in Cases of Abnormal Placental Invasion .

Ain Shams Maternity Hospital50 enrolled

Overview

Cell free fetal DNA might predict abnormal placental invasion

This study aims to evaluate whether measurement of cell-free fetal DNA in the maternal plasma can be predictive of abnormal invasion in cases of placenta previa.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Placenta Accreta Placenta Percreta Placenta Increta Placenta Previa

Interventions

Maternal plasma cell free fetal DNA levelsDIAGNOSTIC_TEST

Measurement Maternal plasma cell free fetal DNA levels in both groups (study and control groups)

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion criteria: 1. Maternal age range from 20-40 years old. 2. Parity: para 1- para 5. 3. Body mass index range from 18-25 kg/m2. 4. Singleton pregnancy carrying male fetuses. 5. Gestational age range from 28-34 weeks. Exclusion criteria: 1. Multifetal pregnancy. 2. Hypertension, preterm labor and intrauterine growth restriction. 3. Patients taking a tocolytic agent or those with uterine bleeding at or after blood sampling. * Since these complications may increase the level of cell-free fetal DNA. 4. Accidental hemorrhage.

Locations (1)

Ain Shams University, Maternity Hospital

Cairo, Egypt

RECRUITING

Outcomes

Primary Outcomes

Predictive value of maternal plasma cell free DNA

Prediction of abnormal placental invasion in cases of placenta previa. Primary aim: Is to evaluate whether measurement of cell-free fetal DNA in the maternal plasma can be predictive of abnormal placental invasion in cases of placenta previa. Secondary aim: To decrease maternal morbidity and mortality by early prenatal diagnosis of abnormal placental invasion in placenta previa

Time frame: 4 months

Secondary Outcomes

maternal morbidity

Time frame: 4 months

Data from ClinicalTrials.gov

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