n-3 Fatty Acids in Enteral Formula on NK Cell Activity

Yonsei University94 enrolled

Overview

The aim of our study was to investigate the NK cell activity alternations and related cytokine changes in comparison with soybean oil used formula (control) and the canola and flaxseed oil used n-3 fatty acid enriched formula (n3EN, test) with non-surgical hospitalized patients for rehabilitation.

Patients were randomized to receive one of two types of enteral nutrition formula: soybean oil used enteral nutrition (control), vegetable (canola, flaxseed) derived n-3 fatty acid enriched enteral nutrition (n3EN). Blood samples were collected on the first day and 14 days after consumption of each formula and anthropometric parameters were collected. Hematology and biochemical values were analyzed and NK cell activities and serum cytokine productions were measured.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Enteral Nutrition

Interventions

vegetable (canola, flaxseed) derived n-3 fatty acidDIETARY_SUPPLEMENT

vegetable (canola, flaxseed) derived n-3 fatty acid was used for fat source.

soybean oilDIETARY_SUPPLEMENT

soybean oil used formula

Eligibility

Sex: ALLMin age: 19 YearsMax age: 100 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients who were admitted to the Severance Hospital Rehabilitation Department , enteral tube feeding patient, Adult male and female patients aged 19 years and over, Patients who signed the consent form Exclusion Criteria: * Patient with nausea * Patients with hepatic impairment (total bilirubin concentration\> 3.5 mg / dl) * Patients with renal impairment (serum creatinine concentration\> 3 mg / dl or requiring peritoneal or hemodialysis) diabetic patients * Patients who are undergoing chemotherapy or who are within 1 month of the end of chemotherapy * Patients whose life expectancy is less than 1 month * Pregnant women and women who are pregnant

Outcomes

Primary Outcomes

NK cell activity

NK cell activity (%)

Time frame: Baseline

Secondary Outcomes

cytokine values

(IL-12, IFN-γ, IL-1β , IL-6 and TNF-α)

Time frame: Baseline

Data from ClinicalTrials.gov

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