Tuberculosis and HIV continue to be major public health problems in resource constrained settings like Zambia. Zambia is among the top 30 highest burden countries globally. The major drivers of TB in the Africa region is the HIV epidemic. Inadequate TB diagnostic tools with failure to make a timely diagnosis and start appropriate treatment are the major impediments to TB control in Zambia and globally.
Project Orion is focused on utilizing Flow Cytometry Technology to screen and diagnose tuberculosis. There are two assays being tested under this Project: 1. Activated TB assay for differentiation of latent and active TB infection using blood samples and 2. Direct TB assay (DTA) for rapid detection and DST of Mycobacterium tuberculosis (Mtb) using sputum specimens.)
Study Type
OBSERVATIONAL
Center for Infectious Disease Research in Zambia (CIDRZ)
Lusaka, Zambia
ATB assay for differentiation of latent and active TB infection using Blood samples
To evaluate the clinical utility of the test reagent(s) compared to diagnostic gold Standard: Culture and Xpert MTB/Rif along with clinical (empiric) diagnosis
Time frame: The duration of this project is 9 months.
DTB assay for rapid detection and drug sensitivity testing of Mtb using sputum specimens
To evaluate the clinical utility of the test reagent(s) compared to diagnostic gold Standard: Culture and Xpert MTB/Rif along with clinical (empiric) diagnosis
Time frame: The duration of this project is 9 months.
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