Central and Peripheral Adiposity and Iron Absorption

Swiss Federal Institute of Technology121 enrolled

Overview

Adiposity is a state of sub-clinical inflammation, thus hepcidin is increased in adiposity, often leading to iron deficiency in this population group. Central adiposity is generally considered having a greater negative effect on health compared to peripheral adiposity. Whether this can be also seen in hepcidin and thereby in iron absorption is uncertain.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

OTHER

Masking

NONE

Enrollment

121

Conditions

Adiposity Iron-deficiency

Interventions

Stable iron isotopesOTHER

Participants have to consume a test meal containing stable iron isotopes in order to determine iron absorption

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * either normal-weight (BMI 18-25kg/m2) or overweight/obese (BMI 28-50kg/m2) with either central or peripheral fat deposits based on DEXA Exclusion Criteria: * Iron Supplement or antibiotic intake within 2 weeks before study start * diagnosed chronic disease or gastrointestinal disorders * regular use of medication (except contraceptives) * pregnancy * lactation * smoking * blood donation or surgery within the last 4 months.

Locations (1)

American University of Beirut

Beirut, Lebanon

Outcomes

Primary Outcomes

Fractional and total iron absorption

Time frame: 14days after the administration of the test meal

Secondary Outcomes

Serum Hepcidin

Time frame: at baseline

Serum ferritin

iron status

Time frame: at baseline

Serum TfR

iron status

Time frame: at baseline

Serum CRP

inflammation status

Time frame: at baseline

Serum AGP

inflammation status

Time frame: at baseline

Serum IL-6

inflammation status

Time frame: at baseline

Data from ClinicalTrials.gov

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