The Use of Gastrografin in Chronic Radiation Enteropathy With Small Bowel Obstruction

Jinling Hospital, China112 enrolled

Overview

Chronic radiation enteropathy (CRE) is a major issue for long-term cancer survivors. The aim of this study was to clarify the diagnostic and therapeutic effect of the Gastrografin (GG) challenge for patients with CRE induced small bowel obstruction SBO.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

112

Conditions

CRE-induced SBO

Interventions

GastrografinDRUG

Patients with CRE-induced SBO or ASBO both received GG challenge.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * with a first diagnosis of CRE combined with SBO and ASBO that was determined by clinical history, computed tomography (CT) manifestation, and conﬁrmed by intraoperative and histologic ﬁndings. * radiation therapy completed at least 6 months before enrolment. Exclusion Criteria: * a colostomy or ileostomy; * large bowel obstruction; * with a known history of either allergy or hypersensitivity to iodinated contrast agents; * with signs of strangulation; * metastatic disease; * obstruction within 4 weeks after a recent operation or serious comorbidity.

Outcomes

Primary Outcomes

The rate of successful conservative treatment

The rate of patients who need for operative intervention within 48 hours of randomization.

Time frame: 5 days

Secondary Outcomes

The time to resolution

The time to resolution of ASIO (flatus and bowel motion).

Time frame: 2 weeks

The length of hospital stays

The length of hospital stays (in hours, calculated from the hospital admission to resolution of intestinal obstruction).

Time frame: 2 weeks

Data from ClinicalTrials.gov

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