Evaluation the Treatment Outcome for RFA in Patients With BCLC Stage B HCC in Comparison With TACE

Inclusion criteria: * age 18 to 75 years ; * HCC confirmed by pathological or clinical diagnosis according to the American Association for the Study of Liver Diseases criteria ; * solitary HCC less than 7cm in diameter or multiple HCC lesions less 5 * the absence of portal/hepatic vein invasion, lymph node involvement and extrahepatic metastases; * lesions visible on ultrasound with a safe path between the lesion and skin; * an Eastern Cooperative Oncology Group performance status of 0-1; * Child-Pugh class A or B cirrhosis. The exclusion criteria : * received any other previous treatment for HCC; * severe coagulation disorders; * evidence of hepatic decompensation including hepatic encephalopathy, ascites as well as esophageal or gastric variceal bleeding; * presence of serious medical comorbidities, including serious dysfunction of the heart or kidney ; * currently had other malignancies in addition to HCC.