Phase II Trial of Fecal Microbiota Transplant (FMT) for VRE and CRE Patients

Inclusion Criteria: * Cognitively intact and willing to provide informed consent * Willing and able to comply with all study procedures for the duration of the study * Age 18 years or older * Two positive stool cultures for CRE or VRE (positive for the same organism on both cultures). The most recent stool culture must be within 14 days of randomization. * Women of childbearing potential in a sexual relationship with men must use an acceptable method of contraception (including, but not limited to, barrier with additional spermicidal foam or jelly, intrauterine device, hormonal contraception started at least 30 days before enrollment into the study, or intercourse with men who underwent a vasectomy) for 4 weeks following completion of the study treatment. * Males must agree to avoid impregnation of women during and for 4 weeks following completion of the study treatment through the use of an acceptable method of contraception (including but not limited to, barrier with additional spermicidal foam or jelly or vasectomy). * Able to take the test capsule successfully with no signs or symptoms of dysphagia. Exclusion Criteria: * Admitted to an intensive care unit (ICU) for medical reasons (not just boarding). Patients residing in a nursing home, long-term care facility or rehabilitation center may be enrolled. * Patient received antibiotics in the last 48 hours. Patients will be eligible to enroll if antibiotic therapy is discontinued for at minimum 48 hours prior to randomization. Does not include antibiotics used for prophylaxis or topical antibiotics. * Requires continued antibiotic use or anticipates antibiotic use in the upcoming 4 weeks. * Unwilling to withhold probiotics for a minimum of 48 hours prior to providing a screening stool sample. * Previous FMT or microbiome-based products in the last 90 days. * Active antibiotic-resistant bacteria (ARB) or gastrointestinal infection at time of enrollment. * Any other gastrointestinal illness including diarrhea. * Known or suspected toxic megacolon and or known small bowel ileus. * Bowel obstruction or other gut motility issues as noted by the patient or in the electronic medical record. * Major gastrointestinal surgery (e.g. significant bowel resection) within 3 months before enrollment not including appendectomy or cholecystectomy. * History of total colectomy or bariatric surgery. * Concurrent intensive induction chemotherapy, radiation therapy, or biologic treatment for an active malignancy. Patients on maintenance chemotherapy may be enrolled after consultation with the medical monitor. * Patients with severe anaphylactic or anaphylactoid food allergy. * Solid organ transplant recipients ≤90 days post-transplant or on active treatment for rejection. * Neutropenia (≤500 neutrophils/mL) or other severe immunosuppression. Anti-tumor necrosis factor (anti-TNF) will be permitted. Participants taking glucocorticoids, antimetabolites (azathioprine, 6-mercaptopurine, methotrexate), calcineurin inhibitors (tacrolimus, cyclosporine) and mycophenolate mofetil may be enrolled only after consultation with the medical monitor. * If At risk of CMV/EBV associated disease (at discretion of investigators, e.g. immunocompromised participant), negative Immunoglobulin G (IgG) testing for cytomegalovirus (CMV) or Epstein Barr Virus (EBV). * Cognitive impairment at the time of enrollment. * Expected life expectancy \<6 months. * Inability (e.g. dysphagia) to or unwilling to swallow capsules. * Unable or unwilling to comply with protocol requirements. * Any condition that would jeopardize the safety or rights of the patient, would make it unlikely for the patient to complete the study, or would confound the results of the study. * Females who are pregnant, lactating, or planning to become pregnant during the study. Female patients of childbearing potential will take a pregnancy test and be excluded if pregnant.