This study aimed to evaluate the additive effect of acetaminophen on postoperative pain control in patients receiving nefopam and fentanyl-based patient-controlled analgesia. Participants undergoing laparoscopic hysterectomy will be randomly assigned to treatment group or control group. After end of surgery, acetaminophen or normal saline (placebo) will be administered intravenously depending on the group assigned.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
84
Acetaminophen will be intravenously administrated to treatment group after the end of surgery.
Seoul National University Hospital
Seoul, South Korea
Total volume of administered analgesics during postoperative 24 hours
morphine equivalent dose of patient-controlled analgesics administered during first 24 hours after end of surgery
Time frame: 24 hours
Pain score
11-point numeric rating scale ranging from '0' representing one pain extreme (e.g. "no pain") to '10' representing the other pain extreme (e.g. "pain as bad as you can imagine" or "worst pain imaginable")
Time frame: 24 hours
Patient satisfaction score
11-point numeric rating scale ranging from '0' representing one extreme (e.g. "extremely dissatisfied") to '10' representing the other extreme (e.g. "extremely satisfied")
Time frame: 24 hours
Postoperative nausea and vomiting
4-scales scoring (none; mild; moderate; severe)
Time frame: 24 hours
Opioid-related adverse effect
Incidence of respiratory, gastrointestinal, and central nervous system complications
Time frame: 24 hours
Use of alternative analgesics
Additional administration of other analgesics
Time frame: 24 hours
Length of stay
Hospital length of stay
Time frame: From date of hospital admission until the date of discharge, an average of 1 week
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