Vitamin D Increases Serum Levels of the Soluble Receptor for Advanced Glycation End Products in Women With PCOS

Maimonides Medical Center79 enrolled

Overview

The purpose of this study is to investigate the mechanism that explain the beneficial clinical effect of vitamin D treatment in women with PCOS.

Seventy-nine women with (n=22) or without (control; n=57) PCOS who were diagnosed with vitamin D deficiency were enrolled. Sixty-three women were treated with oral vit D3 for 8 weeks (16 with PCOS and 47 controls) and 16 women were not treated (6 with PCOS and 10 controls). Serum 25 hydroxy-vitamin D (25 OH-D), sRAGE, and AMH concentrations were measured at baseline and after vit D3 supplementation in the treated group, and 8 weeks apart in the non-treated group. Paired t-test, Wilcoxon signed-rank test, and Pearson correlation were used as appropriate. Main outcome measure: Changes in AMH concentrations following vit D3 replacement.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Polycystic Ovary Syndrome Vitamin D Deficiency

Interventions

Vitamin D3DRUG

Sixty-three vitamin D deficient women (16 with PCOS and 47 without PCOS) were supplemented with 50.000 IU of oral vitamin D3, once weekly for 8 weeks. Serum 25-hydroxyvitamin D (25OH-D), sRAGE and AMH levels were checked before and after treatment.

Eligibility

Sex: FEMALEMin age: 16 YearsMax age: 48 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Vitamin D deficient premenopausal women Exclusion Criteria: * Pregnant women * Women during their postpartum period * Breastfeeding women * Women taking any kind of exogenous hormones * Women receiving any form of oral vitamin D replacement

Locations (1)

Maimonides Medical Center, OBGYN clinic

Brooklyn, New York, United States

Outcomes

Primary Outcomes

AMH Levels in Women With PCOS

AMH measured by serum analysis

Time frame: 8 weeks after completing vitamin D treatment

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.