Bioequivalence of Imeglimin Tablet Formulations

Inclusion Criteria: * BMI : 18.5-29.9 * Body weight ≥ 60 kg * willing to use reliable contraception * able to give fully informed written consent. Exclusion Criteria: * Positive tests for hepatitis B \& C, HIV * severe adverse reaction to any drug; sensitivity to trial medication and/or food allergies * drug or alcohol abuse * smoking of more than 5 cigarettes daily or drinking more than 5 cups of caffeinated drinks daily * over-the-counter medication, vitamins and herbal remedies, or prescribed medication in the 20 days before the first dose of trial medication (with the exception of paracetamol \[acetaminophen\] and oral contraception); * participation in other clinical trials of unlicensed medicines, or loss of more than 400 mL blood, within the previous 3 months * vital signs outside the acceptable range * clinically relevant abnormal findings at the screening assessment; estimated glomerular filtration rate (eGFR) at screening \< 80 mL/min/1.73 m2 * acute or chronic illness * clinically relevant abnormal medical history or concurrent medical condition; * surgery or medical condition that might affect the absorption of medicines; * possibility that volunteer will not cooperate * pre-menopausal females who are pregnant or lactating, or who are sexually active and not using a reliable method of contraception; * objection by the volunteer's General Practitioner (GP).