Observational study to see the effect of use of natural Antioxidant supplement on sperm DNA fragmentation. Subjects will take the natural antioxidant for 3 months prior to repeat testing.
Male patients will be recruited based on having a high DNA fragmentation (chromatin \>16) no other severe male factor infertility (\>5million/ml, count, \> 10%motility and \>1% morphology) and sufficient ejaculate sperm for ICSI (no surgically removed sperm or history of vasectomy reversal). Patients will be provided the natural antioxidant supplementation by the sponsor. Patients will take 1 capsule orally 3 times a day for a full 12 weeks. Sperm DNA structure will be re-assessed after completion of 12 weeks of antioxidant to compare to baseline sperm DNA structure collected prior to starting regimen of supplement daily
Study Type
OBSERVATIONAL
Enrollment
54
1 capsule orally three times a day for 12 weeks
Colorado Center for Reproductive Medicine
Lone Tree, Colorado, United States
Sperm DNA fragmentation
Direct comparison of sperm DNA fragmentation pre and post natural antioxidant exposure
Time frame: 12 weeks
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