Motor Evoked Potentials With Modified Facilitation Technique

University Hospital, Basel, Switzerland81 enrolled

Overview

Investigating the change in Test- Retest- reliability in healthy individuals when applying a modified easy to use facilitation technique compared to standard facilitation technique and analyzing sensitivity and specificity in patients with multiple sclerosis regarding detection of pathologic results

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Multiple Sclerosis

Interventions

MEP using standard facilitation techniqueDIAGNOSTIC_TEST

measuring of MEP using standard facilitation technique according to the Guidelines of International Federation of Clinical Neurophysiology

MEP using modified facilitation techniqueDIAGNOSTIC_TEST

measuring of MEP using modified facilitation technique (application of additional 8-12x magnetic stimuli for arms and legs)

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria for healthy individuals: * Ability to understand the purpose and risks of the study, provide signed and dated informed consent * Between 18 and 65 year of age * No neurologic or psychiatric comorbidity requiring continous treatment * No previous damage of central nervous System Inclusion Criteria for patients: * Ability to understand the purpose and risks of the study, provide signed and dated informed consent * Between 18 and 65 year of age * patients with inflammatory diseases of the central nervous system (CNS) or multiple sclerosis appointed for routine MEP diagnostic at the Department of Clinical Neurophysiology, University Hospital Basel Exclusion Criteria: * Contraindication for measuring of motoric evoked potentials (MEP): metal implants (pacemaker, stents); known epilepsy oder previous epileptic fit * Known disease of the peripheral nervous system (polyneuropathy)

Locations (1)

Dep. of Neurology and Clinical Neurophysiology , Hospital of the University of Basel

Basel, Switzerland

Outcomes

Primary Outcomes

Change in Test- Re-Test reliability when using modified facilitation technique (compared to standard facilitation technique) in healthy individuals

Determination of mean intra-individual difference between measuring time 1 and measuring time 2 and calculation of standard deviation

Time frame: measuring time 2 (75 minutes) maximal 1 month later than measuring time 1 (75 minutes)

comparison of sensitivity and specificity of modified facilitation technique and standard facilitation technique in patients with multiple sclerosis

Determination on the basis of the standard values (established in healthy individuals) in how many patients a pathological result with the modified facilitation technique and the standard facilitation technique is present. Using a a cross-tabulation, the sensitivity and specificity of the modified facilitating technique compared to the standard facilitation technique is measured

Time frame: 1 measuring time (90 minutes)

Data from ClinicalTrials.gov

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