The researchers are trying to reduce the need for blood transfusions in subjects having surgery that will involve the use of cardiopulmonary bypass. A unit of whole blood will be removed as part of their standard of care prior to going on cardiopulmonary bypass (CPB). This unit is given back to the subject post CPB. This has been shown to reduce the need for blood transfusion in patients.
Subjects will be asked to allow the researchers to take the blood left over from normal standard of care blood draws and do coagulation testing. If clinically indicated, the blood, about 2 units, will be withdrawn from the subject. The researchers will also collect 8 ml (less than two teaspoons) of blood through the catheter that was placed as part of standard of care.
Study Type
OBSERVATIONAL
Enrollment
80
Standard coagulation testing (Platelet count, Fibrinogen, PT/INR, aPTT), and Thromboelastogram as is routine and per institutional protocol in this population.
Mayo Clinic
Rochester, Minnesota, United States
Change in Platelet count
A platelet is a tiny piece of cell that is made by breaking off of a large cell in the bone marrow. Platelets are found in the blood and spleen. They help form blood clots to slow or stop bleeding, and to help wounds heal. Also called thrombocyte. Normal platelet count ranges from 150,000 to 450,000 platelets per microliter of blood. Units: 10(9)/L
Time frame: baseline, 30 minutes after cardiopulmonary bypass
Change in Fibrinogen
Component of blood that aids in coagulation. Also known as a blood coagulation factor. Normal reference range 200-393 mg/dL.
Time frame: baseline, 30 minutes after cardiopulmonary bypass
Change in Prothrombin Time/international normalized ratio (PT/INR)
Laboratory test that measures the clotting ability of blood and is a marker for the amount and functionality of the clotting factors in the blood. Normal reference range 0.9-1.1 seconds
Time frame: baseline, 30 minutes after cardiopulmonary bypass
Change in aPTT
Laboratory test that measures the clotting ability of blood and is a marker for the amount and functionality of the clotting factors in the blood. Normal reference range 25-37 seconds.
Time frame: baseline, 30 minutes after cardiopulmonary bypass
Change in Thromboelastogram
Laboratory test that looks at the bloods ability to form a clot and the the strength of the blood clot. It looks at all the components that allow blood to clot as a whole. The visual shape of the test along with objective data provide diagnostic information about normal or abnormal conditions of blood coagulation.
Time frame: baseline, 30 minutes after cardiopulmonary bypass
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Allogenic Blood Transfusion
The amount of Allogenic Blood Transfusion volume required as measured by number of transfused units of red blood cells, platelets, fresh frozen plasma, and cryoprecipitate.
Time frame: 24 hours postoperative
Chest Tube Output
A marker of bleeding in cardiac surgery patients is chest tube output. The amount of fluid as measured in mL's of blood accumulated in the chest tube collection device in 24 hours.
Time frame: 24 hours postoperative
Re-operation
A marker of bleeding in cardiac surgery patients is re-operation. The number of subjects who have re-operation.
Time frame: 24 hours postoperative