Postoperative pain remains relatively high within 48h for Chinese patients who receive video-assisted thoracoscopic surgery. Multimodal analgesia combines several agents and/or techniques to function on diverse nociceptive mechanisms to enhance pain relief and lessen side effect. Hydromorphone is a hydrogenated ketone of morphine and approximately 5-10 times more potent. There lacks about efficacy and efficiency of hydromorphone in electrical pump for patient controlled intravenous analgesic (PCIA).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
171
0.002 mg\*kg-1 bolus with 0.002 mg\*kg-1 background infusion for group BH 0.002 mg\*kg-1 bolus without background infusion for group NBH Drug is administered through PCIA pump.
0.015 mg\*kg-1 bolus without background infusion for group M Drug is administered through PCIA pump.
The second affiliated hospital of Zhejiang University
Hangzhou, Zhejiang, China
Rest pain assessment at 0.5 hour after tracheal extubation
Visual Analogue Scale/Score to assess pain at rest. VAS range from 0 to 100 millimeter. And 0 stands for no pain, while 100 stands for worst pain. Lower value is better.
Time frame: 0.5 hour after tracheal extubation
Rest pain assessment at 8 p.m. surgery day
Visual Analogue Scale/Score to assess pain at rest. VAS range from 0 to 100 millimeter. And 0 stands for no pain, while 100 stands for worst pain. Lower value is better.
Time frame: 8 p.m. at surgery day
Activity pain assessment at 8 p.m. surgery day
Visual Analogue Scale/Score to assess pain on coughing. VAS range from 0 to 100 millimeter. And 0 stands for no pain, while 100 stands for worst pain. Lower value is better.
Time frame: 8 p.m. at surgery day
Rest pain assessment at 8 a.m. at first day after surgery
Visual Analogue Scale/Score to assess pain at rest. VAS range from 0 to 100 millimeter. And 0 stands for no pain, while 100 stands for worst pain. Lower value is better.
Time frame: 8 a.m. at first day after surgery
Activity pain assessment at 8 a.m. at first day after surgery
Visual Analogue Scale/Score to assess pain on coughing. VAS range from 0 to 100 millimeter. And 0 stands for no pain, while 100 stands for worst pain. Lower value is better.
Time frame: 8 a.m. at first day after surgery
Rest pain assessment at 8 p.m. at first day after surgery
Visual Analogue Scale/Score to assess pain at rest. VAS range from 0 to 100 millimeter. And 0 stands for no pain, while 100 stands for worst pain. Lower value is better.
Time frame: 8 p.m. at first day after surgery
Activity pain assessment at 8 p.m. at first day after surgery
Visual Analogue Scale/Score to assess pain on coughing. VAS range from 0 to 100 millimeter. And 0 stands for no pain, while 100 stands for worst pain. Lower value is better.
Time frame: 8 p.m. at first day after surgery
Rest pain assessment at 8 a.m. at second day after surgery
Visual Analogue Scale/Score to assess pain at rest. VAS range from 0 to 100 millimeter. And 0 stands for no pain, while 100 stands for worst pain. Lower value is better.
Time frame: 8 a.m. at second day after surgery
Activity pain assessment at 8 a.m. at second day after surgery
Visual Analogue Scale/Score to assess pain on coughing. VAS range from 0 to 100 millimeter. And 0 stands for no pain, while 100 stands for worst pain. Lower value is better.
Time frame: 8 a.m. at second day after surgery
Rest pain assessment at 8 p.m. at second day after surgery
Visual Analogue Scale/Score to assess pain at rest. VAS range from 0 to 100 millimeter. And 0 stands for no pain, while 100 stands for worst pain. Lower value is better.
Time frame: 8 p.m. at second day after surgery
Activity pain assessment at 8 p.m. at second day after surgery
Visual Analogue Scale/Score to assess pain on coughing. VAS range from 0 to 100 millimeter. And 0 stands for no pain, while 100 stands for worst pain. Lower value is better.
Time frame: 8 p.m. at second day after surgery
Rest pain assessment at 8 a.m. at third day after surgery
Visual Analogue Scale/Score to assess pain at rest. VAS range from 0 to 100 millimeter. And 0 stands for no pain, while 100 stands for worst pain. Lower value is better.
Time frame: 8 a.m. at third day after surgery
Activity pain assessment at 8 a.m. at third day after surgery
Visual Analogue Scale/Score to assess pain on coughing. VAS range from 0 to 100 millimeter. And 0 stands for no pain, while 100 stands for worst pain. Lower value is better.
Time frame: 8 a.m. at third day after surgery
Rest pain assessment at 8 p.m. at third day after surgery
Visual Analogue Scale/Score to assess pain at rest. VAS range from 0 to 100 millimeter. And 0 stands for no pain, while 100 stands for worst pain. Lower value is better.
Time frame: 8 p.m. at third day after surgery
Activity pain assessment at 8 p.m. at third day after surgery
Visual Analogue Scale/Score to assess pain on coughing. VAS range from 0 to 100 millimeter. And 0 stands for no pain, while 100 stands for worst pain. Lower value is better.
Time frame: 8 p.m. at third day after surgery
Ratio of Nausea
Record whether patients experience nausea
Time frame: 8 p.m. at surgery day
Ratio of Vomiting
Record whether patients experience vomiting and how many times do they experience
Time frame: 8 p.m. at surgery day
Ratio of Nausea
Record whether patients experience nausea
Time frame: 8 a.m. at first day after surgery
Ratio of Vomiting
Record whether patients experience vomiting and how many times do they experience
Time frame: 8 a.m. at first day after surgery
Ratio of Nausea
Record whether patients experience nausea
Time frame: 8 p.m. at first day after surgery
Ratio of Vomiting
Record whether patients experience vomiting and how many times do they experience
Time frame: 8 p.m. at first day after surgery
Ratio of Nausea
Record whether patients experience nausea
Time frame: 8 a.m. at second day after surgery
Ratio of Vomiting
Record whether patients experience vomiting and how many times do they experience
Time frame: 8 a.m. at second day after surgery
Ratio of Nausea
Record whether patients experience nausea
Time frame: 8 p.m. at second day after surgery
Ratio of Vomiting
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Record whether patients experience vomiting and how many times do they experience
Time frame: 8 p.m. at second day after surgery
Ratio of Nausea
Record whether patients experience nausea
Time frame: 8 a.m. at third day after surgery
Ratio of Vomiting
Record whether patients experience vomiting and how many times do they experience
Time frame: 8 a.m. at third day after surgery
Ratio of Nausea
Record whether patients experience nausea
Time frame: 8 p.m. at third day after surgery
Ratio of Vomiting
Record whether patients experience vomiting and how many times do they experience
Time frame: 8 p.m. at third day after surgery
Total Analgesia usage
Sum up any extra analgesia when analgesic failure (VAS persistently \> 4) with PCIA pump
Time frame: 8 p.m. at surgery day
Total Antiemetic usage
Sum up any antiemetic
Time frame: 8 p.m. at surgery day
Total Analgesia usage
Sum up any extra analgesia when analgesic failure (VAS persistently \> 4) with PCIA pump from last time point
Time frame: 8 a.m. at first day after surgery
Total Antiemetic usage
Sum up any antiemetic from last time point
Time frame: 8 p.m. at first day after surgery
Total Analgesia usage
Sum up any extra analgesia when analgesic failure (VAS persistently \> 4) with PCIA pump from last time point
Time frame: 8 p.m. at first day after surgery
Total Analgesia usage
Sum up any extra analgesia when analgesic failure (VAS persistently \> 4) with PCIA pump from last time point
Time frame: 8 a.m. at second day after surgery
Total Antiemetic usage
Sum up any antiemetic from last time point
Time frame: 8 a.m. at second day after surgery
Total Analgesia usage
Sum up any extra analgesia when analgesic failure (VAS persistently \> 4) with PCIA pump from last time point
Time frame: 8 p.m. at second day after surgery
Total Antiemetic usage
Sum up any antiemetic from last time point
Time frame: 8 p.m. at second day after surgery
Total Analgesia usage
Sum up any extra analgesia when analgesic failure (VAS persistently \> 4) with PCIA pump from last time point
Time frame: 8 a.m. at third day after surgery
Total Antiemetic usage
Sum up any antiemetic from last time point
Time frame: 8 a.m. at third day after surgery
Total Analgesia usage
Sum up any extra analgesia when analgesic failure (VAS persistently \> 4) with PCIA pump from last time point
Time frame: 8 p.m. at third day after surgery
Total Antiemetic usage
Sum up any antiemetic from last time point
Time frame: 8 p.m. at third day after surgery