Fetal medicine in China is still a new, young discipline, and the development is very rapid. After nearly 10 years of development, the clinical diagnosis and treatment guidelines of some complicated twin diseases has been established , but they are still needed to be improved. Through this study, the investigators expect to achieve better prediction indicators and early intrauterine precise diagnosis of complicated twin diseases. Also, better procedures of implementing effective intrauterine intervention and assessing the safety and effectiveness of intrauterine intervention are anticipated to be established.
A better guideline for complicated twin diseases are anticipated to be established in China. Molecular genetics and imaging technology are applied to evaluate the outcome and prognosis of intrauterine intervention for complex twin diseases. 3D printing technology is used to assist the preoperative evaluation of fetal intrauterine intervention. Better fetal intrauterine intervention technique and prognosis evaluation are expected to be established.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
100
Intrauterine intervention with fetoscope technique will be applied to treat complex twin diseases with intention to improve the prognosis of patients.
Shengjing Hospital
Shenyang, Liaoning, China
RECRUITINGGene expression of fetuses
DNA methylation, histone acetylation etc. assessed by analyses of fetal blood and amniotic fluid.
Time frame: At 20 week of gestational age
Change of volume of amniotic fluid in Milliliter
Measured by doctors of sonography
Time frame: At every two week from the sixteenth week of gestational age to delivery of babies
Change of umbilical artery blood flow
Measured by doctors of sonography
Time frame: At every two week from the sixteenth week of gestational age to delivery of babies
Neurodevelopment at early childhood
Including adaptive, gross motor, fine motor, language, and social function; assessed using Gesell Developmental Schedules.
Time frame: At age of 1 year old
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