Longitudinal Effect of Electroconvulsive Therapy on Schizophrenia and Bipolar Disorder: a MRI Study

Inclusion Criteria: * International classification of diseases (ICD) diagnosis of Schizophrenia and bipolar disorder; * Ages 15-70 * All participants are ethnic Han * Not received ECT treatment before * PANSS ≥ 60 for schizophrenia subjects * The patient's written informed consent can be obtained. If the patient is incapacitated during the onset period, the written informed consent of the legal guardian is required. Exclusion Criteria: * Those with mental retardation, generalized developmental disorders,delirium, dementia, memory impairment or cognitive impairment that meet the diagnostic criteria of ICD-10; * Patients with cognitive impairment, such as Parkinson's, multiple sclerosis, stroke, and patients who meet the diagnostic criteria for ICD-10 alcohol dependence (except nicotine dependence); * The course of the disease is very short (fast phase inversion), such as 4 or more different mood abnormalities (depression, mild mania, mania, mental illness) in one year; * With severe unstable physical diseases; diagnosed diabetes, thyroid disease, hypertension, heart disease, etc.; * Narrow angle glaucoma; * With a history of epilepsy, except those with febrile seizures; * Have or have had drug-induced malignant syndrome and severe tardive dyskinesia; * With serious suicide attempts; * Cannot take medication as directed by their doctors, or who do not have guardians; * Pregnant or lactating women, or those who plan to become pregnant;