Impact of Benralizumab Treatment on Circulating Dendritic Cells in Patients With Eosinophilic Asthma

Inclusion Criteria: 1. Age between 18 and 75 years 2. Patients with severe eosinophilic asthma inadequately controlled despite high-dose inhaled corticosteroids plus long-acting β-agonists. 3. Documented reversibility of airway obstruction (FEV1 increase ≥ 200 ml and ≥ 15 % after inhalation of a short-acting beta agonist) or bronchial hyperresponsiveness to methacholine or histamine 4. Documented concentration of blood eosinophils ≥ 300 / µl blood on the day of study inclusion or in the previous 4 weeks before study inclusion 5. Documented current treatment with high daily doses of ICS plus at least one other asthma controller for at least 3 months at Visit 1. 6. Disease history: asthma exacerbations while on ICS plus another controller. 7. ACQ-6 score ≥ 1.5 at Visit 1. 8. Weight of ≥ 40 kg. 9. Screening pre-bronchodilator (pre-BD) FEV1 of \< 80% predicted 10. Women of childbearing potential (WOCBP)(Definition: WOCBP are those women who have not been surgically sterilized or have not been free from menses for \> 2 years) and male study participants have to use adequate contraception methods. Exclusion Criteria: 1. Smoking history of \> 10 Pack years 2. Current smoking 3. Presence of other chronic pulmonary diseases including COPD 4. Presence of other chronic inflammatory diseases 5. Treatment with any systemic immunosuppressive drug including prednisolone or biologics 6. Current pregnancy, breast feeding 7. Known helminth infections 8. Acute upper or lower respiratory infections within 30 days prior to the date informed consent is obtained or during the screening/run-in period. 9. Any disorder, including, but not limited to, cardiovascular, gastrontestinal, hepatic, renal, neurological, musculosceletal, infectious, endocrine, metabolic, hematological, psychiatric, or major physical impairment that is not stable in the opinion of the Investigator and could: * affect the safety of the patient throughout the study * influence the findings of the studies or their interpretations * impede the patient´s ability to complete the entire duration of study 10. Hypersensitivity to the active substance or to any of the excipients listed in section 6.1 of the SmPC. 11. A helminth parasitic infection diagnosed within 24 weeks prior to the date informed consent is obtained that has not been treated with, or has failed to respond to, standard of care therapy. 12. Any clinically significant abnormal findings in physical examination, vital signs, hematology, or clinical chemistry during screening period, which in the opinion of the investigator may put the patient at risk of his/her participation in the study, or may influence the results of the study, or the patient´s ability to complete entire duration of the study. 13. Any clinically significant cardiac disease or any electrocardiogram (ECG) abnormality which in the opinion of the Investigator may put the the patient at risk or interfere with study assessments. 14. A history of known immunodeficiency disorder including a positive human immunodeciency virus (HIV) test. 15. Current malignancy, or history of malignancy, except for: Patients who have had non-melanoma skin cancer or in situ carcinoma of the cervix are eligible provided that the patient is in remission and curative therapy was completed at least 12 months prior to the date informed consent is obtained. Patients who have had other malignancies are eligible provided that the patient is in remission and curative therapy was completed at least 5 years prior to the date informed consent is obtained. 16. Concurrent biologics for asthma are not allowed except for stable allergen immunotherapy (defined as a stable dose and regimen at the time of Visit 1). Acceptable washout periods or other asthma biologics: * Other eosinophil lowering products indicated for asthma (including reslizumab or mepolizumab): at least 4 months. * Prior omalizumab use: 1 month. 17. Any immunosuppressant systemic medication (including systemic glucocorticoids) or treatment with antibodies targeting the immune system. 18. Receipt of any investigational medication as part of a research study within approximately 5 half-lives prior to randomization 19. Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) level \> 3 times of the upper limit of normal (ULN) confirmed during screening period. 20. Receipt of immunoglobulin or blood products within 30 days prior to the date informed consent is obtained. 21. Receipt of live attenuated vaccines 30 days prior to the date of randomization; other types of vaccines are allowed. 22. Planned surgical procedures during the conduct of the study. 23. Concurrent enrolment in another interventional or post-authorization safety study.