Achalasia is a rare esophageal motility disorder. Treatment of achalasia is aimed toward palliation of symptoms. These include botox injections to the lower esophageal sphincter (LES), pneumatic dilation, surgical myotomy, and per-oral endoscopic myotomy (POEM). Botox injections are frequently used for patients that have significant comorbidities. The primary aim of this study is to assess symptomatic response of patient with achalasia to esophageal dilation and botox injection to the LES compared to standard therapy of only botox injection.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
50
Botox injection in the LES
Distal esophageal dilation
Subjects will complete two patient reported outcome measures (Eckardt and MADS).
Vanderbilt University Medical Center Endoscopy Laboratory
Nashville, Tennessee, United States
dysphagia score
Dysphagia score as measured by patient reported outcomes will be used to compare the two groups. The scale runs from 0 (no symptoms) to 100 (severe symptoms).
Time frame: 12 months
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Assess for radiologic severity of achalasia with barium column height measured 1 minute and 5 minutes after upright ingestion of barium