Role of Dienogest in the Treatment of Patient With Symptomatic Adenomyosis

Assiut University100 enrolled

Overview

Adenomyosis was first described as endometrial glands in the myometrium of the uterus. The current definition of adenomyosis is provided in 1972 'the benign invasion of endometrium into the myometrium, producing a diffusely enlarged uterus which microscopically exhibits ectopic non-neoplastic, endometrial glands and stroma surrounded by the hypertrophic and hyperplastic myometrium

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

100

Conditions

Adenomyosis

Interventions

DienogestDRUG

oral tablets

Combined Oral ContraceptiveDRUG

oral tablets

Eligibility

Sex: FEMALEMin age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * symptomatic adenomyosis * irregular menstrual bleeding and dysmenorrhea . Exclusion Criteria: * asymptomatic patients - * non-lactating patient * not desire for pregnancy * no hormonal treatment more than 6 month even contraception e.g IUD * no focal lesion of uterus (malignancy ,fibroid or adenxal mass )

Outcomes

Primary Outcomes

The mean pain score after receiving treatment

assessment by visual analog scale

Time frame: 6 months

Data from ClinicalTrials.gov

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