Study of Obesity Control by Astragalus and Notoginseng Extrats

Chung Shan Medical University38 enrolled

Overview

The effects of the Astragalus and Notoginseng extrats on obesity control was demonstrated in a randomized double-blind, and crossover human trial.

Obesity refers to the body due to physiological or biochemical function of the change caused by excessive accumulation of body fat, resulting in weight gain. Hence, the aim of this study was to evaluate the effects of the Astragalus and Notoginseng extrats on obesity control by a randomized double-blind and crossover human trial. Subjects with simple obesity (body mass index (BMI) ≥ 27 or body fat ≥ 30%) ingested 5 extrats (n = 19) capsules or placebo (n = 19) perday for 12 weeks of a stage. Anthropometric measurements (body weight, body fat, blood pressure) and blood biochemical markers including fasting blood glucose (FBG), albumin, total cholesterol (TC), triglyceride (TG), HDL-C, LDL-C, creatinine (Cr), blood urea nitrogen (BUN), AST, ALT were examined every six weeks.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Obesity

Interventions

InnoSlimDIETARY_SUPPLEMENT

Subjects ingested 2 capsules (Experimental group) in the morning and 3 capsules in the evening (5 capsules/d) for 12 weeks of a stage. Anthropometric measurements such as body weight, body fat, waistline, hipline, blood pressure (systolic blood pressure \[SBP\] and diastolic blood pressure \[DBP\]) and blood biochemical parameters including FBG, albumin, TC, TG, HDL-C, LDL-C, Cr, BUN, AST and ALT were measured every six weeks.

PlaceboDIETARY_SUPPLEMENT

Subjects ingested 2 capsules placebo in the morning and 3 capsules in the evening (5 capsules/d) for 12 weeks of a stage. Anthropometric measurements such as body weight, body fat, waistline, hipline, blood pressure (systolic blood pressure \[SBP\] and diastolic blood pressure \[DBP\]) and blood biochemical parameters including FBG, albumin, TC, TG, HDL-C, LDL-C, Cr, BUN, AST and ALT were measured every six weeks.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Body mass index (BMI) ≥ 27 or body fat ≥ 30%; * No history of serious diseases associated with heart, liver, kidney, endocrine systems or other organs; * No drugs consumption. Exclusion Criteria: * BMI \>35; * Alcoholic; * US-controlled diabetics; * Stoke in past one year; * High blood pressure; * Mental diseases or melancholia; * Pregency or breast-feeding a child.

Outcomes

Primary Outcomes

The changes of body weight and BMI of the subjects.

values change of body weight and BMI between before to after 12 weeks

Time frame: 12 weeks

Secondary Outcomes

The changes of triglyceride (TG) of the subjects

values change of triglyceride (TG) between before to after 12 weeks

Time frame: 12 weeks

Data from ClinicalTrials.gov

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