Impact of Periodontal Treatment on Gastric Helicobacter Pylori Eradication

Ondokuz Mayıs University98 enrolled

Overview

The efficacy of conventional systemic antibiotic therapy for eradication of gastric H. pylori has been seriously challenged by antibiotic resistance. Identification of alternative therapeutic strategies might help to overcome the limitation. The investigators' aim was to examine the effect of adjunct periodontal therapy, on gastric H. pylori eradication rate.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Helicobacter Pylori Infection

Interventions

Triple therapyDRUG

triple therapy:a 10-day course of a Lansoprazole (proton pump inhibitor )combined with amoxicillin (2 × 1 g daily) and clarithromycin (2 × 500 mg daily).(trio)

professional periodontal treatmentPROCEDURE

periodontal treatment consisting of mechanical periodontal treatment (scaling and root planing) Oral hygiene insruction Periodontal treatment started concurrently with triple therapy

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * tested positive for H. pylori both in gastric biopsy specimens and dental plaque samples Exclusion Criteria: The patients who had treatment with following medications within 6 months before the clinical protocol: * had antibiotics * had Proton pump inhibitor (PPI), * had H2 blockers, and * took bismuth derivatives * had previous eradication therapy, or * had previous periodontal therapy * Edentulous patient * Diabetic patients * pregnant patients

Outcomes

Primary Outcomes

eradication rate of gastric H. pylori infection

The follow-up was done by a 14C-urea breath test at least 12 weeks after completion of treatment . A 14C urea breath test analyzer (HUBT-20; Headway, Guangdong, China) was used to diagnose H. pylori infection

Time frame: 3 months

Secondary Outcomes

oral H. pylori eradication

Oral H. pylori infection was tested by CLO test Plaque samples were collected from tooth surfaces with a sterile periodontal curette, then immediately inoculated onto CLO test gel.

Time frame: 3 months

periodontal parameters (Probing depth)

probing depth used as a surrogate marker to measure periodontal disease severity

Time frame: 3 months

Clinical Attachment level

used as a surrogate marker to measure severity of the periodontal disease

Time frame: 3 months

OHI (Oral Hygiene Index)

this index used to determine patient oral hygiene status (Greene and Vermillion, 1964)

Time frame: 3 months

Gingival Index

Löe-Silness gingival index

Time frame: 3 months

Plaque index

this index used to determine patient oral hygiene status (Silness-Löe)

Time frame: 3 months

Bleeding on Probing

an index give information on inflammation status of periodontal tissues

Data from ClinicalTrials.gov

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