Short-interval pregnancy (SIP) or rapid, repeat pregnancy is defined as a pregnancy within one year of prior delivery. These pregnancies are often unintended and are associated with adverse risks. Low contraceptive initiation during the postpartum period is a contributing factor to SIP. This study will be the first to investigate the initiation of a highly-effective, immediately active contraceptive device during the antepartum period. The antepartum period serves as an ideal time for postpartum contraception counseling, due to patients' active involvement with the healthcare system. The pharmacokinetic analysis proposed in this study will be the first to investigate whether and to what extent ENG hormone crosses the placenta. This data will enrich understanding of the pharmacology of exogenous progestins administered during pregnancy and provide information that can be incorporated into future patient counseling regarding the risks of fetal exposure with exogenous progestin use.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
PREVENTION
Masking
NONE
Participants will have an etonogestral contraceptive implant (NEXPLANON) placed sub-dermally just under the skin at the inner side of the non-dominant upper arm.
University of Colorado Denver
Aurora, Colorado, United States
Maternal and cord blood serum etonogestrel concentration
Maternal and cord blood serum etonogestrel concentratration
Time frame: Delivery
Gestational age at time of delivery
Gestational age at time of delivery
Time frame: Delivery
Onset of lactogenesis
Stage II of lactation
Time frame: 5-10 days postpartum (Follow Up Visit 1)
Questionnaire: Continuation of contraceptive implant use
Assess continuation of the contraceptive implant
Time frame: 3 months postpartum (Follow Up Visit 2)
Questionnaire: Satisfaction with contraceptive implant
Assess satisfaction with the contraceptive implant
Time frame: 3 months postpartum (Follow Up Visit 2)
Questionnaire: Continuation of contraceptive implant use
Assess continuation of the contraceptive implant
Time frame: 6 months postpartum (Follow Up Visit 3)
Questionnaire: Satisfaction with contraceptive implant
Assess satisfaction with the contraceptive implant
Time frame: 6 months postpartum (Follow Up Visit 3)
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