T2* MRI Analysis for Sarcoma

Bryan Allen8 enrolled

Overview

T2\* imaging is a method to identify labile iron pools in tumor cells. These iron pools may be linked to better treatment outcomes for specific types of therapy. This is a small pilot study to see if radiation therapy changes the amount of iron in a sarcoma tumor.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Radiotherapy Magnetic Resonance Imaging Sarcoma

Interventions

T2* ImagingDIAGNOSTIC_TEST

T2\* imaging sequences for MRI

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * pathologically confirmed Sarcoma, by biopsy or excision * prescribed radiation therapy as per standard of care * treatment to begin within 5 weeks after surgery or biopsy * ECOG 0, 1, or 2 * ability and willingness to provide informed consent Exclusion Criteria: * \< 18 years of age

Locations (1)

Holden Comprehensive Cancer Center

Iowa City, Iowa, United States

Outcomes

Primary Outcomes

Change in ferric iron levels detected by T2* MRI

Change from baseline in Fe3+ iron levels

Time frame: baseline and 8 weeks

Secondary Outcomes

Change in ferrous iron levels detected by T2* MRI

Change from baseline in Fe2+ iron levels

Time frame: Baseline and 8 weeks

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.