Palliative Radiotherapy to Dominant Symptomatic Lesion in Patients With Hormone Refractory Prostate Cancer

Inclusion Criteria: 1. Patients with hormone refractory biopsy proven prostate cancer 2. Presenting with a dominating debilitating symptom 3. Expected median survival of 12 months 4. Focal irradiation of lesion is feasible 5. Systemic therapy according to guidelines 6. age ≥18 years 7. Legal capacity, able to understand consequences of the trial 8. Written informed consent Exclusion Criteria: 1. Relevant comorbidity (limiting radiotherapy according to protocol) 2. Prior radiotherapy limitations to administer radiotherapy according to protocol 3. No large metal implants in vicinity of lesion 4. Department dose constraints for normal tissue can't be met 5. Large bony lesions with extensive osseous destruction 6. Patients symptoms do not correlate with MR findings