Evaluation of Rebamipide and Rabeprazole Effect Associated or Not to Prevent Naproxen-induced Gastric Lesions

Inclusion Criteria: * Volunteers of both sexes aged 18 or over. Women could not be pregnant or breastfeeding * Body-mass index (BMI) ≥19.0 kg/m² and ≤ 28.75 kg/m² * Good state of health * Non-smoker or ex-smoker for at least 6 month * Written informed consent, after having been informed about benefits and potential risks of the clinical trial, as well as details of the insurance taken out to cover the subjects participating in the clinical trial Exclusion Criteria: * Existing cardiac, hepatic and/or haematological diseases or pathological findings, which might interfere with the safety or tolerability and/or pharmacokinetics and/or pharmacodynamics of the active ingredient * History of relevant central nervous system (CNS) and/or psychiatric disorders and/or currently treated CNS and/or psychiatric disorders * Known allergic reactions to the active ingredients used or to constituents of the pharmaceutical preparations * Subjects with severe allergies or multiple drug allergies, unless it is judged as not relevant for the clinical trial by the investigator * Volunteer does not present the entire upper gastrointestinal tract mucosa, that is, hemorrhages, ulcers or apparent lesions at the first endoscopic examination. * The volunteer that has achlorhydria (intragastric pH greater than 6.5) * Occult blood in the faeces with positive result before the start of therapy * Electrocardiographic findings not recommended by the researcher for participation in the study * Deviations from the results of laboratory recruitment examinations considered clinically relevant by the researcher * Has a history of alcohol or drug abuse or expressive alcohol consumption (\> 35g/day) * Participation in a clinical trial during the last 6 months prior to individual enrolment of the subject * Have used regular medication within 2 weeks prior to initiation of treatment or used any medication within one week prior to initiation of study treatment, with the exception of oral contraceptives or cases where, based on half-life of the drug and/or active metabolites, complete elimination may be assumed * Subjects who are unable to understand the written and verbal instructions, in particular regarding the risks and inconveniences they will be exposed to during their participation in the clinical trial