Prebiotic Effects of a Polyphenol-rich Food Product

Iowa State University25 enrolled

Overview

The specific aim for this project will be to investigate a cranberry beverage as a means to restore balance in terms of the relative proportions of the various bacteria that inhabit the large intestine.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Dysbiosis

Interventions

Cranberry beverageOTHER

During the intervention period, research participants will consume a cranberry beverage daily.

Placebo beverageOTHER

During the intervention period, research participants will consume a placebo beverage daily.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * BMI 27-35 kg/m2 * High waist circumference (men \>102 cm and women \>88 cm) Exclusion Criteria: * Cigarette smoking * Regular intensive exercise * Pregnancy or lactation * Chronic diarrhea, constipation, or other gastrointestinal complaint * Diabetes mellitus, autoimmune disease, or other chronic disease known to alter the gut microbiota * Use of medications that affect inflammation or the gut microbiota * Use of prebiotics, probiotics, synbiotics, vitamins, or other dietary supplements known to affect the gut microbiota * Aversion to cranberries * Food allergies * Lactose intolerance * Vegetarianism

Locations (1)

Nutrition and Wellness Research Center

Ames, Iowa, United States

Outcomes

Primary Outcomes

Fecal microbial community composition and structure

We will investigate if specific bacterial taxa are stimulated by daily consumption of a cranberry beverage.

Time frame: Changes in the fecal microbiota will be measured after a 20-day intervention period

Data from ClinicalTrials.gov

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