Melatonin is secreted from the epiphyseal gland with a circadian rhythm and is known to be anti-inflammatory. In this study, it is planned to investigate the effect of sleep disruptions on melatonin levels and inflammation parameters in intensive care patients underwent transcranial surgery
Patients with Glasgow coma scale (GKS) \>14, American Society of Anesthesiologist (ASA) I-III, intensive care patients underwent transcranial surgery will be included Patients will be randomly allocated by a computer generated random numbers list into two groups. Patients with sleep disruptions (Group I) (exposed to ambient light and noise) and Patients without sleep disruptions (Group II) (eyes closed with patch and ear plugged; between 24:00-06:00) Melatonin levels will be measured by urine 6-sulfatoxymelatonin (a-MT6) levels, which is a product of melatonin degradation at 07:00 am preoperative and postoperative day 1 and day 3. Plasma Interleukin-1 (IL-1), Interleukin- 6 (IL-6),C-reactive protein (CRP) levels will be measured at 07:00 am preoperative and postoperative day 1and day 3.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Enrollment
41
Eyes closed with patch and ears plugged between 24:00-06:00
Universty of Health Sciences, Dıskapı Yıldırım Beyazıt Training and Research Hospital
Ankara, Turkey (Türkiye)
Melatonin level
Melatonin will be measured urine 6-sulphatoxymelatonin
Time frame: At preoperative 07:00 am
Melatonin level
Melatonin will be measured urine 6-sulphatoxymelatonin
Time frame: 07:00 am postoprative day 1
Melatonin level
Melatonin will be measured urine 6-sulphatoxymelatonin
Time frame: 07:00 am postoprative day 3
IL-1,IL-6,CRP
serum
Time frame: : at 7 o'clock in the morning preoperative day, 7 in the morning on the first postoperative day and 7 in the morning on the third postoperative day hour
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