Diabetic cardiomyopathy (DCM) is a distinct clinical entity of diabetic heart muscle that describes diabetes associated changes in the structure and function of the myocardium in the absence of coronary artery disease, hypertension, and valvular disease. Oxidative stress plays a critical role in DCM development. DCM can be diagnosed using the novel methods of echocardiography (tissue Doppler imaging, Speckling tracking techniques and more recent real time 4D echocardiography). There is a possible cardioprotective effect of statins, Captopril and L-Carnitine in type 1 diabetic children and adolescents.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
150
cardio-protective agents
cardio-protective agents
cardio-protective agents
Faculty of Medicine- Tanta University
Tanta, Gharbia Governorate, Egypt
The cardiac changes induced by Simvastatin, captopril and L-Carnitine in type 1 diabetic children and adolescents.
Corrected QT interval(QTc) and QT dispersion in ElectroCardioGram
Time frame: before and after 4 months of receiving cardio-protective agents
The cardiac changes induced by Simvastatin, captopril and L-Carnitine in type 1 diabetic children and adolescents.
Left Ventricular End Systolic Volume (ml). Left Ventricular End Diastolic Volume (ml). Ejection Fraction (EF %) and left ventricular strain using echocardiography.
Time frame: before and after 4 months of receiving cardio-protective agents
The role of Troponin I levels as a cardiac marker for detection of asymptomatic cardiovascular insult in diabetic children.
Serum Cardiac troponin I by Enzyme Linked ImmunoSorbant Assay
Time frame: first day
The role of recent echocardiographic parameters for early detection of silent myocardial dysfunction
Echocardiography
Time frame: first day
Identification of risk factors for developing diabetic cardiac insult.
Time frame: first day
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