Iron Bioavailability of High Surface Area Ferric Phosphate

Swiss Federal Institute of Technology18 enrolled

Overview

The primary objective of this study is to compare iron absorption of high surface area ferric phosphate with that of ferrous sulfate and bulk ferric phosphate in a rice-based meal in non-pregnant women.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Iron-deficiency

Interventions

FeSO4 fortified rice test mealDIETARY_SUPPLEMENT

Rice test meal extrinsically labeled with 2 mg ferrous sulfate (58FeSO4)

FePO4 fortified rice test mealDIETARY_SUPPLEMENT

Rice test meal extrinsically labeled with 2 mg ferric phosphate (58FePO4)

HiFePO4 1 fortified rice test mealDIETARY_SUPPLEMENT

Rice test meal extrinsically labeled with 2 mg high surface ferric phosphate 1 (57FePO4)

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 49 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Women of reproductive age (18 to 49 years) in Thailand * BMI \< 23 kg/m2 * Body weight \< 65 kg * Mildly anaemic to normocythemic (Hb 80-110 g/L) * Ferritin \< 25 µg/L * Not pregnant (confirmed by pregnancy test stripe) or lactating * No inflammation (CRP \< 5 mg/L) * Having provided written informed consent Exclusion Criteria: * Haemoglobinopathies (except heterozygosity for haemoglobin E and alpha-thalassemia 1) * Coeliac disease or other chronic diseases of malabsorption that could influence iron absorption or metabolism * Blood donation or significant blood loss due to surgery or accident \< 4 months before start of the study * Consumption of vitamin or mineral supplements 2 weeks before start of the study * Regular use of medication (except oral contraceptives), that influences iron absorption * Chronic inflammatory disease * Smoking

Locations (1)

Mahidol University

Salaya, Changwat Nakhon Pathom, Thailand

Outcomes

Primary Outcomes

Fractional iron absorption

Iron absorption will be determined by measurement of the isotopic ratio change from the 4 different types of iron vehicles (FeSO4 fortified rice test meal, FePO4 fortified rice test meal, HiFePO4 1 fortified rice test meal, HiFePO4 2 fortified rice test meal).

Time frame: Measured 14 days after consumption of the 4 different types of iron vehicles (Days 16 and 31)

Data from ClinicalTrials.gov

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