The Effect of Rapid Fluid Challenge Under Pulmonary Artery Catheter Monitoring on Physiological Indexes of Patients With Septic Shock

Chengdu Fifth People's Hospital100 enrolled

Overview

Fluid challenge is often carried out in septic shock patients. Its responsiveness usually requires invasive monitoring. The pulmonary artery catheter(PAC) is the most effective means of monitoring.To use non-invasive methods is very tempting. Investigators hypothesize that venous-to-arterial carbon dioxide difference,venous-to-arterial carbon oxygen difference, central venous-arterial carbon dioxide to arterial-venous oxygen content ratio and Central Venous SO2 variations provides feasible estimation on fluid responsiveness in septic shock patients.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

100

Conditions

Septic Shock

Interventions

fluid chanllenge

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * more than 18 years old; less than 75 years old ICU patients * Septic shock * Monitored with pulmonary artery catheter (Swan-Ganz catheter) * The decision of fluid challenge made by the treating physician Exclusion Criteria: * Evidence of fluid overload * Pregnancy * Recently participated in other studies * Severe heart failure

Outcomes

Primary Outcomes

cardiac index change

Fluid responsiveness: increase in CI of at least 10% after fluid challenge ;Fluid nonresponsiveness:no increase or increase in CI less than 10%.

Time frame: Immediately after fluid challenge