The purpose of this study is to look at the amount of the study drug, LY3074828, that gets into the blood stream and how long it takes the body to get rid of LY3074828 when given as different formulations. The tolerability of LY3074828 will also be evaluated and information about any side effects experienced will be collected. Screening is required within 28 days prior to the start of the study. For each participant, the study will last about 12 weeks, not including screening.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
66
Administered SC
Administered SC
AI to administer LY3074828
Covance Clinical Research Inc
Daytona Beach, Florida, United States
Pharmacokinetics: Maximum Concentration (Cmax) of LY3074828 by Device
Pharmacokinetics: Cmax of LY3074828
Time frame: Day 1: 0, 2, 6 hours (hr), Day 2: 24 hr, Day 4, Day 8, Day 11, Day 15, Day 22, Day 29, Day 43, Day 57, Day 71, Day 85, Post dose
Pharmacokinetics: Area Under the Concentration Versus Time Curve From Time Zero to Infinity (AUC(0-∞)) of LY3074828 by Device
Pharmacokinetics: Area Under the Concentration versus Time Curve From Time Zero to Infinity (AUC(0-∞)) of LY3074828
Time frame: Day 1: 0, 2, 6 hours (hr), Day 2: 24 hr, Day 4, Day 8, Day 11, Day 15, Day 22, Day 29, Day 43, Day 57, Day 71, Day 85, Post dose
Visual Analogue Scale (VAS) Pain Assessment by Device
The VAS is a single-item participant-rated assessment of injection pain. Score is reported on a continuous scale of 0 to 100. Higher values indicate more pain.
Time frame: Day 1: 1, 5 (±1.5) and 15 (±2) minutes
Visual Analogue Scale (VAS) Pain Assessment by Device and Injection Site Location
The VAS is a single-item participant-rated assessment of injection pain. Score is reported on a continuous scale of 0 to 100. Higher values indicate more pain.
Time frame: Day 1: 1, 5 (±1.5) and 15 (±2) minutes
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
PFS to administer LY3074828