Circadian Rhythms in Patients With IBD or Celiac Disease Upon Diagnosis and Medical Follow-up

Tel-Aviv Sourasky Medical Center80 enrolled

Overview

patients 6-25 years old upon diagnostic evaluation will be recruited . study population will comprise of two groups: newly diagnosed IBD patients/ Celiac disease and healthy controls. upon enrollment, subjects will fill out sleeping habits questioners, demographic data, medical history. blood samples will be drawn for CRP and clock gene expression in systemic WBC. intestinal biopsies will be snap frozen for clock gene extraction and amplification only for patients with IBD.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Inflammatory Bowel Diseases Circadian Dysregulation

Interventions

no intervention performed- observational onlyOTHER

no intervention performed- observational only

Eligibility

Sex: ALLMin age: 6 YearsMax age: 25 Years

Medical Language ↔ Plain English

Inclusion Criteria: * IBD or celiac patients with a confirmed diagnosis, recruited upon diagnosis. * Both male and female * Age 6-25 years * Medically treated for IBD in our institute. Exclusion Criteria: * Genetic disorder. * Known primary or secondary immunodeficiency . * Pregnancy or lactating

Locations (1)

Tel Aviv Sourasky Medical Center

Tel Aviv, Israel

Outcomes

Primary Outcomes

clock gene expression levels in intestinal mucosal samples and WBC peripheral blood.

PCR amplification levels

Time frame: 4 years

Data from ClinicalTrials.gov

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