Vienna Consensus has identified 10% damage rate after ICSI as a competency value. Despite the highest quality embryologists doing ICSI, degeneration sometimes occurs due to oocyte factors such as the fragile membrane, etc. Cytochalasin B serves to facilitate spindle or pronuclear transfer procedures helping to reduce the damage rate with no harm reported. Using Cytochalasin B during ICSI could serve to rescue some oocytes from the degeneration allowing for more chances of viable zygotes,
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
987
A medium with in-house supplementation of Cytochalasin B to decrease oocyte degeneration after ICSI and improve survival rate
IbnSina IVF Center
Sohag, Egypt
oocyte survival rate
number of survived oocyte after intracytoplasmic sperm injection
Time frame: 6 days of culture
fertilization rate
number of fertilized oocytes per metaphase II injected
Time frame: 6 days of culture
blastocyst formation rate
number of formed blastocyst per fertilized oocyte
Time frame: 6 days of culture
embryo utilization rate
number of embryo transferred added to number of those cryopreserved per fertilized oocyte
Time frame: 6 days of culture
clinical pregnancy rate
number of women with a heartbeat at week 4 or more after embryo transfer
Time frame: three months
ongoing pregnancy rate
number of women with continued pregnancy after twelve weeks of gestation
Time frame: four months
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