The aim of this work is to compare the clinical outcomes of letrozole with laparoscopic ovarian drilling (LOD) in patients with clomiphene-citrate-resistant polycystic ovary syndrome (PCOS).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
90
2.5 mg letrozole oral tablets will be administered on the 2nd-3rd day of menses and then every day for 5 days. Treatment will be repeated for up to three cycles if the patient failed to conceive.
Bilateral laparoscopic ovarian drilling, each ovary will be cauterized at 4 points, each for 4 sec at 40 W, at a depth of 7-8 mm and a diameter of 3-5 mm, using a monopolar electrosurgical needle according to the size of each ovary.
Ain shams university maternity hospital
Cairo, Egypt
RECRUITINGOVULATION RATE
SERUM PROGESTERON LEVEL
Time frame: 7 DAYS BEFORE NEXT MENSES
BIOCHEMICAL PREGNANCY RATE
BY SERUM HCG
Time frame: AFTER 30 DAYS OF INTERVENTION
CLINICAL PREGNANCY RATE
BY FETAL HEART RATE MONITORING BY ULTRASOUND SCAN
Time frame: AT 6 WEEKS GESTATION
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