Impact of Cannabis Oil on Nutrition in Hemodialysis Patients Study (ICON-HP Study)

Inclusion Criteria: * Male or female, age \> 18 years, on MHD hemodialysis treatment at least 3 months * Stable and adequate hemodialysis treatment three months prior to participation in study as defined by Kt/V \> 1.2 and/or hemodialysis performed 4 hours 3 times weekly * Patients with Malnutrition-Inflammation Score (MIS) ≥ 6 * Informed consent obtained before any trial-related activities Exclusion Criteria: * Previous or current use in cannabis or marijuana * Critical illness as defined by the need of respiratory or circulatory support * Known or suspected allergy to trial products * Females of childbearing potential who are pregnant, breast-feeding or intend to become pregnant or are not using contraceptive methods * Patients with active malignant disease or liver cirrhosis * Actively symptomatic gastrointestinal bleeding and inflammatory bowel disease * Patients on chronic treatment with steroids on doses \> 10 mg/day Prednisone (or equivalent) * Patients treated with immunosuppressive agents * Patients receiving any of the following medications: Astemizole, Cisapride, Pimozide or Terfenadine * Patients suffering from: * Acute vasculitis * Severe systemic infections * Severe Heart failure (NYHA class IV) * Severe hepatic disease, defined as ALT or AST levels \>3 times upper normal range * Mental incapacity, unwillingness or language barrier * Any condition judged by the investigator to interfere with trial participation or evaluation of results or to be potentially hazardous to the patient * A significant history of alcohol, drug or solvent abuse * History of schizophrenia, affective disorder, history of psychiatric hospitalization and diagnosed anxiety disorder * The receipt of any investigational drug within 1 month prior to initiating of this study * Scheduled renal transplantation (fixed date).