Conduct a prospective study in multicenter to confirm the value of circulating tumor DNA in longitudinal monitoring of stage III-IV lung cancer patients.
The study consists of two phases, the first stage is the exploratory stage of blood collection point which is the appropriate effective time after chemotherapy, radiotherapy, targeted therapy. The second phase, which is the expansion of the first phase, is to determine the precise leading time of ctDNA relative to tumor biomarkers or image evaluation in determining the efficacy of advanced NSCLC cancer therapy. Both stages were divided into three subgroups: the chemotherapy group, the radiotherapy group, and the targeted therapy group.
Study Type
OBSERVATIONAL
Enrollment
120
Peking University People's Hospital
Beijing, Beijing Municipality, China
RECRUITINGAffiliated Hospital of Hebei University
Baoding, Hebei, China
RECRUITINGHebei Medical University Fourth Hospital
ctDNA effective time
To explore the appropriate chemo/ radio/ target effective time (CET/RET/TET) through measurement and monitoring of ctDNA after anti-cancer therapies in advanced NSCLC.
Time frame: 6 months
ctDNA leading time
To investigate the precise leading time for ctDNA compared to conventional biomarker or image evaluation in detecting disease recurrence after radiotherapy, chemotherapy, or targeted therapy respectively.
Time frame: 1 year
Assess the accuracy of ctDNA
To assess the accuracy of ctDNA when imaging undetectable or difficult to assess
Time frame: 1 year
Compared to conventional image
Compared to conventional image evaluation, to determine the consistency of ctDNA in treatment response of measurable lesion after radiotherapy, chemotherapy, or targeted therapy respectively
Time frame: 1 year
Compared to traditional tumor markers
To explore the consistency for ctDNA in determining the efficacy of advanced NSCLC compared to tumor markers after radiotherapy, chemotherapy, or targeted therapy respectively
Time frame: 6 months
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Shijiazhuang, Hebei, China
The First Hospital of Shijiazhuang
Shijiazhuang, Hebei, China
RECRUITINGXingtai People's Hospital
Xingtai, Hebei, China
RECRUITINGHandan Downtown Hospital
Handan, Heibe, China
RECRUITINGTianjin Medical University Cancer Institute and Hospital
Tianjin, Tianjin Municipality, China
RECRUITINGTianjin Medical University General Hospital
Tianjin, Tianjin Municipality, China
RECRUITING