To describe the design, methodology and baseline characteristics of the Shanghai Cohort study of Diabetic Eye disease (SCODE) study, a community-based study to determine the prevalence and impact of diabetic eye disease, especially diabetic retinopathy (DR), in adults with diabetes living in Shanghai.
The Shanghai Cohort study of Diabetic Eye disease (SCODE) was a three-year community-based study to carry out a regular ocular health screening and epidemiological analysis for diabetic eye disease in the approximately 8,000 middle-aged and elderly people with diabetes in Shanghai. Through this study, we hope to understand the prevalence, epidemic trend and the features of risk factors distribution on diabetic eye disease, especially on DR. Meanwhile, our aims also included estimating the ocular fundus changes and visual impairment associated with different grade of DR. Furthermore, the aim of the present study was to investigate the association between serum and urine biochemical parameters and DR.
Study Type
OBSERVATIONAL
Enrollment
8,000
Community-based, prospective cohort study from three consecutive years (2016 to 2018) to determine the prevalence and impact of diabetic eye disease, especially diabetic retinopathy (DR), in adults with diabetes living in Shanghai.
Prevalence and incidence rate of diabetic eye disease
SCODE was performed to evaluate the prevalence and rate of new cases of diabetic eye disease, especially DR, in a three-year community-based cohort study for the people with diabetes, and to identify the associated factors related with diabetic eye disease.
Time frame: December 31, 2018
Grading of DR
Fundus changes were evaluated on non-mydriatic fundus photography and slit-lamp examination. Meanwhile, we will estimate the fundus changes associated with different grade of DR.
Time frame: December 31, 2018
Retinal and choroidal thickness
Retinal and choroidal thickness were evaluated on SS-OCT.
Time frame: December 31, 2018
Retinal blood flow
Retinal blood flow were evaluated on SD-OCTA.
Time frame: December 31, 2018
Blood biochemistry indexes
Blood samples were used for testing, including glucose, glycosylated hemoglobin (HbA1C), serum lipids, etc.
Time frame: December 31, 2018
Urine biochemistry indexes
Urine samples were used for testing urine albumin and creatinine.
Time frame: December 31, 2018
Visual impairment
Main Cause of visual impairment were determined by two ophthalmologists based on the ophthalmic examinations and reported history. Moreover, we will evaluate the association between the visual impairment and different grade of DR.
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Time frame: December 31, 2018