Nimotuzumab for Recurrent Nasopharyngeal Carcinoma

Inclusion Criteria: 1. Patients with recurrent tumor in nasopharynx with or without relapse cervical lymph nodes more than 6 months after initial radical treatment. 2. Recurrent nasopharyngeal cancer was confirmed by pathology, marginal recurrence can be diagnosed by imaging examinations. 3. Age 18-70. 4. At least one of the tumor lesions measurable. 5. Functional Status: PS (ECOG) \> 0-1. 6. Normal Bone Marrow Function: White blood cell count \> 4×109/L, hemoglobin \>90g/L, and platelet count \>100×109/L. 7. Normal Hepatic and Renal Function: Alanine Tminotransferase (ALT)/Aspartate Aminotransferase (AST) \< 2.5 times the upper limit of normal (ULN), while total bilirubin (T-Bil) \< 1.5 x ULN and serum creatinine \< 1.5 x ULN. 8. Life expectancy of more than 6 months. 9. All the patients signed the informed consent. 10. Follow up regularly and comply with test requirements. Exclusion Criteria: 1. Patients with recurrent cervical lymph nodes alone. 2. Evidence of distant metastasis 3. The relapse tumor has been treated with chemotherapy, radiotherapy, surgery, immunotherapy and other anti-tumor therapy. 4. Creatinine clearance \< 30ml/min 5. Has received epidermal growth factor targeting therapy. 6. Second malignancy within 5 years(except of Non-melanoma Skin Cancer or carcinoma in situ of cervix). 7. Serious complications, such as uncontrolled hypertension, coronary heart disease, diabetes, heart failure, etc. 8. Active systemic infection. 9. History of Serious lung or heart disease. 10. Drug or alcohol addiction. 11. Persons without capacity for civil conduct or persons with limited capacity for civil conduct. 12. The patient has physical or mental disorders and is believed to be unable to fully or fully understand the possible complications of the study. 13. To receive chronic systemic immunotherapy or hormone therapy other than this study. 14. Women who are pregnant or breast feeding 15. Participation in other drugs clinical trials within 1 month.