Taiwan Cohort - Chronic ThromboEmbolic Pulmonary Hypertension Registry

National Taiwan University Hospital200 enrolled

Overview

The diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH) is difficult for numerous reasons and is related with a poor prognosis. In Taiwan, the incidence of CTEPH and its clinical features are unknown. This study aims at evaluating the prevalence, clinical characteristics, and management of CTEPH in a Taiwanese cohort. Primary objective: \- To investigate the geodemographics of CTEPH in Taiwan Secondary objectives: * To characterize the demographics and clinical presentation of patients with CTEPH * To describe the real-world management and treatment outcome of patients with CTEPH * To identify the risk factors of CTEPH * To assess the relationship between risk factors/patients' characteristics and clinical outcomes for CTEPH * To evaluate the prognosis of CTEPH in Taiwan using survival assessment

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

The Geodemographics of CTEPH in Taiwan

Eligibility

Sex: ALLMin age: 20 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Right heart catheterization (RHC) results that are in line with both of the following haemodynamic levels: Mean pulmonary arterial pressure (mPAP) ≥ 25 mmHg at rest AND Pulmonary arterial wedge pressure (PAWP) ≤ 15 mmHg 2. Confirmation of CTEPH diagnosis by one of the following as recommended by standard guidelines: At least 1 (segmental) perfusion defect(s) in ventilation-perfusion (V/Q) / perfusion scan OR Pulmonary artery obstruction seen by multidetector computed tomography (MDCT) angiography or conventional pulmonary cineangiography. 3. Presence of pulmonary hypertension or evidence of pulmonary thromboembolism after at least 3 months of anticoagulation treatment. Exclusion Criteria: * not written informed consent * not meet inclusion criteria

Outcomes

Primary Outcomes

To investigate the geodemographics of CTEPH in Taiwan

variables of interest also include (1) patients characteristics, such as demographics and medical history; (2) clinical features and diagnosis records, such as risk factors, comorbidities, CTEPH diagnosis data, concomitant conditions; (3) management of CTEPH, including surgery and medication; and (4) clinical outcome including clinical assessment results, survival status, and clinical worsening related to CTEPH.

Time frame: recruiting period two years

Secondary Outcomes

To characterize the demographics and clinical presentation of patients with CTEPH - To describe the real-world management and treatment outcome of patients with CTEPH - To identify the risk factors of CTEPH - To assess the relationship between risk f

detail information descriptive in protocol