Genetic Predisposition to Breast and Ovarian Cancer: Prospective Study of BRCAx Gene Mutation

N/ARecruitingNCT03667417

Institut Paoli-Calmettes5,000 enrolled

Overview

Cohort of subjects carrying a BRCA gene mutation: genetic predispositions to breast and ovarian cancers

Study Type

OBSERVATIONAL

Enrollment

5,000

Conditions

Breast Cancers Ovarian Cancers

Interventions

QuestionnairesOTHER

standardized data collection and 10-year prospective follow-up

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

1. Woman or man, with or without cancer, carrying a deleterious BRCA1/BRCA2 mutation, aged 18 years and over. 1. Woman with or without breast cancer or ovarian cancer at baseline. 2. Man with or without breast cancer at baseline. 2. Signed consent to participation 3. Affiliation to a social security regimen, or beneficiary of such a regimen. Exclusion Criteria: 1. A person of legal age subject to a legal protection measure, or unable to express consent. 2. Impossibility to submit to the follow-up of the test for geographical, social or psychological reasons

Locations (1)

Institut Paoli-Calmettes

Marseille, France

RECRUITING

Outcomes

Primary Outcomes

Incidence of breast and / or ovarian cancer during subject lifetime

risk that a subject with a mutation develops breast and / or ovarian cancer during his lifetime, assessed by epidemiologic questionnaires (carcinologic events).

Time frame: 10 years

Central Contacts

Dominique GENRE, MD

CONTACT

33 491 22 37 78 DRCI.UP@ipc.unicancer.fr

Margot BERLINE, MSc, MBA

CONTACT

33 491 22 33 14 DRCI.UP@ipc.unicancer.fr

Data from ClinicalTrials.gov

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