Evaluation of Novel Lung Function Parameters in Patients With Pulmonary Hypertension (PH)

Universitätsmedizin Mannheim75 enrolled

Overview

Little is known about affection of small airways in patients with pulmonary hypertension as well as the ideal diagnostic approach. The investigators therefore aimed to evaluate novel or not widely used lung function tests for the evaluation of airway function in patients with PH.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Pulmonary Hypertension

Interventions

body plethysmographyDIAGNOSTIC_TEST

measurement of conventional lung function parameters

impulse oscillometryDIAGNOSTIC_TEST

measurement of central and peripheral airway resistance

multiple breath washoutDIAGNOSTIC_TEST

measurement of ventilation heterogeneity

Eligibility

Sex: ALLMin age: 18 YearsMax age: 99 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * known or first diagnosis of PH Exclusion Criteria: * inability to perform lung function testing * unable or unwilling to participate

Outcomes

Primary Outcomes

LCI

between-group difference in lung clearance index (LCI)

Time frame: 30 minutes

D5-20

between-group difference in frequency dependence of resistance (D5-20)

Time frame: 30 minutes

Secondary Outcomes

Discrimination small airway resistance

Evaluation of discriminative capability of impulse oscillometry

Time frame: 30 minutes

Discrimination ventilation heterogeneity

Evaluation of discriminative capability of multiple breath washout

Time frame: 30 minutes

Data from ClinicalTrials.gov

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