A Phase I/III Clinical Study of TPX-114 for the Treatment of Full-Thickness Rotator Cuff Tear

Inclusion Criteria: Participants must; 1. Be 19 years of age or older. 2. Require arthroscopic repair for full-thickness rotator cuff tear(\>2cm, ≤5cm) assessed by MRI without improvement of symptoms despite more than 3 months of conservative management. 3. Consent to undergo skin biopsy to manufacture test product. 4. Understand fully the study and voluntarily sign the informed consent for participation in the study. Exclusion Criteria: Participants with any of the following conditions will be excluded unless stated otherwise; 1. Unsuitable for skin biopsy. 2. Have additional subscapularis tear. 3. Have prior medical history of the following at the time of screening. * Operation of the affected shoulder * Allergies to bovine proteins * Anaphylaxis to gentamicin * Coagulopathy * Genetic disorders affecting fibroblasts or collagen (ex. achondroplasia, osteogenesis imperfecta) * Malignant tumors within the last 5 years 4. Have been diagnosed with any of the following diseases at the time of screening. * Autoimmune disease (including RA) * HIV Ab-positive * Acute trauma, chronic shoulder dislocation, pyogenic infection on the affected shoulder * Scapulohumeral osteoarthritis 5. Be pregnant, breastfeeding, planning pregnancy or unwilling to use of contraceptives suggested in this study. 6. Other surgical or nonsurgical procedures on the affected shoulder to be judged more appropriate than arthroscopic repair. 7. Have participated in and received investigational agents in other clinical trials within 4 weeks of this study. 8. Be deemed inadequate for the study by investigators.